Background. Glomerular filtration rate (GFR) is a measure of how much blood is filtered by the kidneys
each minute accordingly is considered as the best overall indicator for how well an individual's kidneys
are functioning at a given moment.GFR cannot be measured directly in people. Objective of the study.
To bring out the difference between estimation of GFR via commonly used different methods and
compare them using clearance measures or serum levels of filtration indicators. Material and Methods.
Study design - descriptive. WHO information sources, scientific papers from the PubMed database on
different methods of estimation of GFR were studied using the selected keywords and the following
criteria 1)English language 2)10 and more citations of the article 3)publications within 10 years Results.
In both the immature and mature kidney, urinary clearance of inulin, remains the reference against which
alternative clearance techniques and filtration indicators are assessed. GFR in newborns is assessed
using creatinine, the most extensively used GFR measure in adults. Cystatin C is less affected by muscles
than creatinine, but eGFR based on serum cystatin C (eGFRcys) is not more accurate than eGFRcr,
because of various conditions affecting non-GFR determinants of serum cystatin-C. However, equations
combining both these filtration markers(eGFRcr-cys) appear to be more precise than equations using
either marker alone. Conclusion. The glomerulus filters inulin freely, and is neither released or
reabsorbed in the tubules, and is nor synthetized or metabolized. As a result, urine inulin clearance is
regarded as the golden standard for diagnosis.
Background. Glomerular filtration rate (GFR) is a measure of how much blood is filtered by the kidneys
each minute accordingly is considered as the best overall indicator for how well an individual's kidneys
are functioning at a given moment.GFR cannot be measured directly in people. Objective of the study.
To bring out the difference between estimation of GFR via commonly used different methods and
compare them using clearance measures or serum levels of filtration indicators. Material and Methods.
Study design - descriptive. WHO information sources, scientific papers from the PubMed database on
different methods of estimation of GFR were studied using the selected keywords and the following
criteria 1)English language 2)10 and more citations of the article 3)publications within 10 years Results.
In both the immature and mature kidney, urinary clearance of inulin, remains the reference against which
alternative clearance techniques and filtration indicators are assessed. GFR in newborns is assessed
using creatinine, the most extensively used GFR measure in adults. Cystatin C is less affected by muscles
than creatinine, but eGFR based on serum cystatin C (eGFRcys) is not more accurate than eGFRcr,
because of various conditions affecting non-GFR determinants of serum cystatin-C. However, equations
combining both these filtration markers(eGFRcr-cys) appear to be more precise than equations using
either marker alone. Conclusion. The glomerulus filters inulin freely, and is neither released or
reabsorbed in the tubules, and is nor synthetized or metabolized. As a result, urine inulin clearance is
regarded as the golden standard for diagnosis.