Abstract:
We have followed up 67 patients with acute promyelocytic leukemia, who underwent
combined treatment with ATRA and polychemotherapy (PCT). Complete remissions were
achieved in 55 (82,1%) cases. Early relapses were registered in 9 (34,6%) patients. Late relapses
developed in 17 ( 66.4%) cases, four of these patients abolished the treatment. Relapses more
often (82,4%) develop in the patients in first 3 years of complete remision, but in following
years the frecvency of relapses is significantly reduced.Repeated combined treatment with
ATRA and PCT appeared to be efficient in 5 (23,8%) cases.
Key words: Acute promyelocytic leukemia, All-trans-retinoic acid, relapse.
Sub supraveghere s-au aflat 67 de bolnavi de leucemie acută promielocitară, care au
primit tratament cu ATRA în combinaţie cu polichimioterapie. Remisiuni complete au fost
obţinute la 55 (82,1%) bolnavi. Recidive precoce au fost constatate la 9 (34,6%) pacienţi,
recidive tardive în 17 (66,4%) cazuri. Recidivele mai frecvent (82,4%) au aparut în primii 3 ani
de remisiune completă, ulterior cu scăderea lor considerabilă. Remisiune completă în
tratamentul recidivelor a fost obţinută la 5 (23,8%) bolnavi.
