Recidivele leucemiei acute promielocitare

Abstract

We have followed up 67 patients with acute promyelocytic leukemia, who underwent combined treatment with ATRA and polychemotherapy (PCT). Complete remissions were achieved in 55 (82,1%) cases. Early relapses were registered in 9 (34,6%) patients. Late relapses developed in 17 ( 66.4%) cases, four of these patients abolished the treatment. Relapses more often (82,4%) develop in the patients in first 3 years of complete remision, but in following years the frecvency of relapses is significantly reduced.Repeated combined treatment with ATRA and PCT appeared to be efficient in 5 (23,8%) cases. Key words: Acute promyelocytic leukemia, All-trans-retinoic acid, relapse.

Sub supraveghere s-au aflat 67 de bolnavi de leucemie acută promielocitară, care au primit tratament cu ATRA în combinaţie cu polichimioterapie. Remisiuni complete au fost obţinute la 55 (82,1%) bolnavi. Recidive precoce au fost constatate la 9 (34,6%) pacienţi, recidive tardive în 17 (66,4%) cazuri. Recidivele mai frecvent (82,4%) au aparut în primii 3 ani de remisiune completă, ulterior cu scăderea lor considerabilă. Remisiune completă în tratamentul recidivelor a fost obţinută la 5 (23,8%) bolnavi.