Abstract:
Introduction
Deep leiomyomas are benign neoplasms, which are rarely
encountered, with location other than the gynecological
tract. These neoplasms exhibit smooth muscle
differentiation and can be located in the deep soft tissue,
retroperitoneum, mesentery, omentum, within the
abdominal cavity and have an increased prevalence in
women.
Purpose
The aim of our study is to provide useful information on
some aspects of the immunohistochemical profile
underlying this specific type of tumor.
Material and methods
Our study involved 2 cases of postmenopausal women
with clinical diagnosis of retroperitoneal tumor. We
examined paraffin-embedded tissue sections cut at 3µm
and stained with hematoxylin-eosin. A large panel of
immunohistochemical markers were used including the
following: Anti-PCK, EMA, S100, Vim, ER, PR,
Melanosome, HMB45, Ki67, Desmin, SMA, CD34,
Caldesmon.
Results
Histologically, they are
classic leiomyomas,
similar to those
encountered in the
gynecological tract. LM
are composed of spindle
cells with smooth muscle
morphology: oval nuclei,
frequently with blunt
ends (cigar-shaped),
perinuclear clear
vacuoles and fibrillary
eosinophilic cytoplasm. Conclusions
Deep leiomyomas occur
preferentially in women during
the perimenopausal period, and
most commonly have a
retroperitoneal location. These
tumors are commonly positive for
estrogen and progesterone.
