Abstract:
Introduction: Osteoarthritis is characterized by degeneration
of articular cartilage. There are several molecular factors of
chondrocyte apoptosis that contribute to the degradation of
cartilage in osteoarthritis, but do not yet constitute therapeutic
targets for its treatment.
Material and methods: This research represents a detailed
synthesis of bibliographic sources published abroad in
scientific databases in the years 2015-2020. I have accesed the
following search engines: PubMed, Google Scholar, Hinari.
Purpose: Synthesis of bibliographic data to determine the
molecular factors of chondrocyte apoptosis involved in the
pathogenesis of osteoarthritis.
Results: Analyzing the bibliographic sources, the review articles
performed at the international level, a series of molecular
markers involved in the pathogenesis of osteoarthritis were
highlighted: NO, caspase-1, -3, -6, -7, -8 and -9, tumour
suppressor protein p53, MAPK, NFkB, c-myc, death receptor Fas,
C-terminal PARP-1 fragment, Toll-like receptors ½, TNF-alfa,
transforming growth factor beta, calcium-binding S100 proteins,
matrix metalloproteinase-13, fibronectin, Bax, Bak, Bid, Bad, Bim,
Bik, IL-1, leptin.
Conclusions: The existence of a large number of molecular
factors involved in the chondrocyte apoptosis offers a multitude
of potential targets for pharmacological treatment of
osteoarthritis.
