Carnosine – a new therapeutic option in diabetic nephropaty

Abstract

Introduction Highly concentrated in the brain, heart, liver, kidneys and muscles, carnosine is a natural antioxidant and anti-glycation molecule which is quickly broken down by our body’s enzyme carnosinase. Because of its anti-glycation properties, carnosine is researched as a way to combat the dangers of insulin resistence and high blood sugars in both those with pre and established diabetes. Purpose To study the biochemical mechanisms of carnosine action and to appreciate the benefits of carnosine therapy as a potential treatment option in preventing kidneyrelated complications in diabetes. Material and methods The basis of this work is a comprehensive literature synthesis including the analysis of multiple academic reports, studies and clinical trials from 10 bibliographic sources published in electronic libraries like PubMed, Medscape and Hinari. Results - Reduced urine albumin creatinine ratio - Reduced basement membrane thickening - Protection from glomerular degeneration and podocyte number preserved.