Abstract:
Introduction.
Some studies show an association between the occurrence of
neuroimaging changes (MRI) and Vigabatrin treatment in West
syndrome in children, all changes being reversible and dose dependent.
Purpose.
Evaluation of neuroimaging peculiarities
secondary to Vigabatrin treatment based
on a clinical case.
Material and methods.
We evaluated the case of a 1-year-old 7-month-old boy
diagnosed with West syndrome who was hospitalized in
2019 in the Hospital of Mother and Child Health Care where
he received treatment with Vigabatrin. At the age of 6 months
the child presented the clinical picture of infantile spasms
and delay in neuropsychic development, being diagnosed
with West syndrome. The first neuroimaging investigation MRI was performed at the age of 8 months, and the repeated
one after 6 months of treatment with Vigabatrin
Results.
The child performed the first brain MRI, where
periventricular cysts, a minimized volume of cerebral
white matter with periventricular gliosis, with
reduction of hippocampal volume and enlargement of
the ventricular and cisternal system were described.
After the initiation of Vigabatrin treatment, the
seizures stopped. The same changes were described
on the repeated MRI examination (after 6 months),
but small gliotic lesions appeared in the brainstem and
tegmetum, which were not previously described.
Conclusions.
Brain MRI changes may be seen in children with epilepsy treated
with Vigabatrin. These may include increased signal in T2 and
transient changes in the brainstem, usually being dose dependent
and disappearing after discontinuation of treatment.
Description:
USMF “Nicolae Testemițanu”, Departamentul Pediatrie,
USMF “Nicolae Testemițanu”, Laboratorul de genetică,
USMF “Nicolae Testemițanu”, Departamentul Pediatrie,
USMF “Nicolae Testemițanu”, catedra de Neurologie nr.2,
USMF “Nicolae Testemițanu”, Departamentul Pediatrie
