Abstract:
Introduction
The fight against TB is impossibile when are ignored the
measures for prevention and detection of the relapses.
The patients with relapse are an important reservoir of
infection and account between 2 and 30% of all TB
cases. Relapsed TB requires “retreatment” regimen that
is more toxic, longer, amplifies the drug resistance and
diminished the outcome.
Purpose
The aim was the assessment of the risk factors for the
relapse of the pulmonary drug susceptible and multidrugresistant (MDR-TB) tuberculosis.
Material and methods
Was realized a retrospective and longitudinal study which
included 119 patients with relapse distributed in 2 groups: 1
st
Group – 57 cases with drug-susceptible TB and the 2
nd Group –
62 cases of MDR-TB relapse
Results
Distribution according to sex: male/female ratio=5,3/1 in 1
st
Group and 3,8/1 in 2
nd Group (X2<0,001), age <44 years
prevailed in 2
nd Group 35 (57%) vs 26 (43%) in 1
st Group. Early
relapse (in the first 2 years after treatment completion)
predominated in the 1
st Group - 9 (16%) vs 6 (10%) in 2
nd
Group, late relapse in 2
nd G -32 (71%) vs 36 (63%) in 1
st Group.
History of detention prevailed in the 2
nd Group – 11 (18%) vs 3
(5%) in 1
st Group (X2<0,001, OR=4,1 CI:1,3-17,8), low
economical state 50 (81%) in 1
st Group vs 33 (58%) in 2
nd
Group (X2=0,002, OR=3,1 CI:1,3-6,9), and comorbidities 19
(31%) in 1
st Group vs 14 (25%) in 2
nd Group.
Conclusions
The risk factors for the relapse of the MDR-TB were history of
detention, which is associated with a close contact and social
vulnerability, low economic status and low financial income. No
statistical differences were identified regarding the age
distribution and comorbidities among the patients with drug
susceptible and MDR-TB relapse.
