Abstract:
Introduction: From all the methods, nuclear magnetic resonance (NMR) is one that offers the
richest and the most complete structural information about organic compounds. This method can be
applied to the elucidation of chemical structure as well as the determination of stereochemistry and
conformation of their pure substance and mixture. The interpretation of the NMR spectrum
becomes an increasingly empowered ability applied in the context of the rapid development of
organic synthesis of new compounds, and in the increasing interest for the existing drug substances.
Purpose and Objectives: The highlighting of the main stages of NMR interpretation
spectrum, the structure elucidation of organic compounds and determination of their
stereochemistry and conformation.
Materials and methods: The study is performed by meta-analysis of published scientific
data, standardization of analytical quality documents, articles from magazines and periodicals.
Results: As a result of the study was formulated an algorithm of the interpretation of NMR
spectrum. We applied the rules established in the analysis of NMR spectrum, which gave us information
about the structure of substances and their conformation. The data that were obtained correlate with the
data from the scientific literature and confirm the applicability of the formulated algorithm.
Conclusion: The right interpretation of the NMR spectrum, allows the accurate identification
of the structure of an unknown substance, with any molecular weight and any number of molecules,
as well as isomers differentiation between them.
