Antimicrobial resistance/sensibility of microorganisms mostly involved in the etiology of septic-purulent infections

Abstract

Introduction: Antimicrobial resistance is one of the major risks for the global health security. This phenomenon is particularly characteristic of septic-purulent infections. Materials and methods: During 2013 were identified and tested with VITEK 2 Compact system 884 strains of microorganisms with GP-21342 cards for Gram-positive microorganisms and GN-21341 for the gram-negative. Number of tested strains were: S. aureus-146. Enterococcus spp.- 41, A. baumanii-92, Enterobacter spp. - 81, E. coli—130, Citrobacter spp. -15, Morganella spp. -7 , Proteus spp. -76, P. aeruginosa-161, Klebsiella spp.-108, Serratia spp.-10 and other microorgan ism s-17. Results: Producing of extended spectrum beta lactamase (ESBL) was 72,2% of the strains K. pneumoniae, E. coli strains of 37,5% and 23,5% K. oxytoca. Resistance to methici 1 lin were 27 strains of S. aureus (18.5%), and four strains were producing enzymes responsible for inducible resistance to clindamycin. Resistance to vancomycin showed 7,5% of the strains of Enterococcus spp., antibiotic which is one of the few options that may be used in the treatment of infections due to enterococci. Against carbapenems, higher resistance showed strains of P. aeruginosa-5 1,18% Proteuss spp.-18,67% , Serratia spp.-25% , Klebsiella spp.-10,60% , Enterobacter spp.-8.82% and E. coli-2,70% . A. baumanii strains were resistant to carbapenems only one sample, and Citrobacter spp. and Morganella spp. were susceptible to carbapenems. Against third generation cephalosporins, the resistance of strains of microorganisms often involved in producing septicpurulent infections were much higher. More resistant to cephalosporins have proved to be microorganisms of the genus Klebsiella sp p .- 68.84%, Proteus spp -56.30% , Enterobacter spp. -43.45% , E. coli - 33.85%. Conclusion: Studied microorganisms show high resistance to antibiotics, especially to third generation cephalosporins. Dynamic monitoring is necessary in order to preserve one of the latest treatment options of septic-purulent infections.