Determination of level of leptin in patients with obesity and component of metabolic syndrome

Abstract

Introduction: Obesity is the chronical polyetiological disease, which associated with some genetical and neurological factors, changes of functions of endocrine system, one of the serious factors of occurrence of diabetes II, essential hypertension, dyslipidemia, cardiovascular disease, reproductive disorders. In the basis of disorders of metabolic processes and occurrence of listed above conditions lying the resistance to insulin. Leptin has links with weight of adipose tissue, effect on insulinemia and resistance to insulin. Aim of study: Analyze BMI, level of leptin, cholesterol and triglycerides in blood in patients with obesity (I, II, III lvl.) with components of metabolic syndrome, such as: diabetes II and essential hypertension. Materials and methods: Since 2013 to 2014 we examine the 28 patients aged from 38 to 65 years old (19 female and 9 male). In this group the 11 patients were ill with obesity of first level, 9 patients - obesity of second level and 8 patients - obesity of third level. All patents were ill with moderate diabetes in phase of subcompensation. During the examination in all patients was the condition of metabolism of carbohydrate, lipid, protein, electrolyte and instrumental examination. Discussion results: On the basis of examination, in the patients with obesity of first level, the BMI was 32,00 ± 0,38 kg\m2, level of leptin - 34,84 ± 6,40 ng\ml, level of cholesterol - 5,89 ± 0,31 mmolM and level of triglycerides - 2,36 ± 0,9 mmolM. In the patients with obesity of second level, the BMI was 39,20 ± 0,49kg\m2, level of leptin - 35,48 ± 6,34ng\ml, level of cholesterol - 5,35 d 0,36mmol\l and level of triglycerides - 270 ± 0,41 mmolM. In the patients with obesity of third level, the BMI was 32,00 ± 0,38 kg\m2, level o f leptin - 69,99 ± 5,3ng\ml, level o f cholesterol - 5,86 ± 0,77mmol\l and level of triglycerides - 2,67 ± 0,42mmol\l. Results of study suggest that level of leptin, cholesterol and triglycerides increased in patients with obesity and component of metabolic syndrome. Conclusions: 1. In patients with obesity and component of metabolic syndrome the level of leptin, cholesterol and triglycerides was increased. 2. Preventive health care and treatment of obesity promotes the prevention of increased levels of leptin, cholesterol and triglycerides.