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The opportunity of persistent viral infection in clinical and immunological manifestation of community-acquired pneumonia

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dc.contributor.author Şcerbatiuc, Corina
dc.contributor.author Mihailişin, Nicolaie
dc.contributor.author Maximciuc, Ştefan
dc.date.accessioned 2021-12-16T11:59:11Z
dc.date.available 2021-12-16T11:59:11Z
dc.date.issued 2014
dc.identifier.citation ŞCERBATIUC, Corina, MIHAILIŞIN, Nicolaie, MAXIMCIUC, Ştefan. The opportunity of persistent viral infection in clinical and immunological manifestation of community-acquired pneumonia. In: MedEspera: the 5th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2014, p. 51. en_US
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/19442
dc.description State Medical and Pharmaceutical University „Nicolae Testemitanu”, Chisinau, Republic of Moldova en_US
dc.description.abstract Introduction: Pneumonia is the cause of death of more then 2 mln children every year, which represents approximately 20% from all deaths. In RM the prevalence is 140-150 at 1000 of children. According to WHO, the mortality caused by herpetic infection is placed on 2nd place (15.8%) in group of viral infections, followed by H. influenzae. Death rate in CM V infection is evaluated at 30 %, and 80% -100% of the survivors will develop such sequelaes as: progressive deafness, mental retardation, microcephaly. Affectation of respiratory system at children with CMV infection is estimated at 49%, clinical manifested by respiratory distress syndrome and pneumonia. Objectives: To highlight the risk factors and determine the clinical and immunological particularities of CAP associated with persistent viral infection. Materials and Methods: 1. Examination of medical cards. 2. Paraclinical Examination (hemoleucogram, biochemical examination, immunological examination using the Mancini’s method - IgA, IgG, IgM; anti - CMV serological examination, anti - CMV - IgA; 3. Screening methods: chest X-ray, internal organs Eco; 4. Consultation of Infectionist, gastroenterologist, psycho-neurologist, allergist, etc.; 5. The obtained investigations results were statistically processed by using variational and descriptive analysis in Microsoft Excel statistic programs. In each group we had the follow age structure: 1-6 months, 6-12 month, 1-3 years, and 3-5 years. The distribution in study groups was the similar as in the control one. Results: From 106 children with CAP: 1st lot: Anti-CMV IgM positive, Anti-CMV Ig G positive - 31; 2nd lot: Anti-CMV IgM negative; Anti-CMV Ig positive - 44; 3rd lot: Anti-CMV IgM negative; Anti-CMV IgG negative - 31; 1. Risk factors that determine the severe evolution of CAP at infants with positive herpetic IgM or IgG are herpetic family history 61.3%, in special with MV 43.07 %. 2. Clinical diagnostic markers in suspicion of persistent viral infection - family persistent viral history, congenital pneumonia, prolonged neonatal jaundice, toxic hepatitis. 3. The association of CAP with IgM positive herpetic infection, appreciate the severity of disease (35.48±1.4%, p<005), its duration (more than 1 month, 2 week of hospitalization) and the presence of complications (83.8±2.35%, p<0,005) and comorbidities at this children. Conclusions: The herpetic infection is an important risk factor that needs to be evaluated and be very seriously studied. Persistent herpetic viral infection can be qualified as a medico-social problem, because of its clinical and immunological manifestation, distribution, amplitude and comorbidities and we must take an attitude behind this problem, as soon as possible. en_US
dc.language.iso en en_US
dc.publisher Ministry of Health of the Republic of Moldova, State Medical and Pharmaceutical University Nicolae Testemitanu, Medical Students and Residents Association en_US
dc.relation.ispartof MedEspera: The 5th International Medical Congress for Students and Young Doctors, May 14-17, 2014, Chisinau, Republic of Moldova en_US
dc.subject recurrent respiratory diseases en_US
dc.subject community-acquired pneumonia en_US
dc.subject persistent viral herpetic infection en_US
dc.subject children under 5 years en_US
dc.title The opportunity of persistent viral infection in clinical and immunological manifestation of community-acquired pneumonia en_US
dc.type Other en_US


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  • MedEspera 2014
    The 5th International Medical Congress for Students and Young Doctors, May 14-17, 2014

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