Determination of vaso-regulator’s concentration level in men and women with essential hypertension

Abstract

Introduction: The role of endothelin-1 (ET-1) as vasoconstrictor (VC) and marker of vascular endothelial dysfunction has been well studied, however the properties of vasodilator (VD) C-type natriuretic peptide (CNP) continue to be explored. We can assume that their ratio reflects the balance VD / VC. Purpose and objectives: Study of the correlation between concentrations of CNP and ET-1 in male and female patients with essential hypertension (EH). Materials and Methods: We have examined 119 men and 139 women, including 79 healthy men (mean age 54.64 ± 0.40 years) and 80 women (57.49 ± 0.48 years) of the control group. In 40 men (mean age 55.01 ± 0.36 years) and 50 women (56.91 ± 0.36 years) AH II-III degree was diagnosed. In all examined patients the levels of CNP and ET-1 were determined by immunoenzyme method. We have also calculated patient’s correlation index using Cl (SNP/ET-1). Discussion results: It was revealed that the quantity of Cl in males of the control group was lower than in women: (1.39 ± 0.02 u) and (1.44 ± 0.04 u), respectively. The CNP level was higher in men, and ET-1 in females (p < 0.05). Significant Cl differences depending on the sex of the patients were not identified. Conclusion: Changes in the levels of CNP and ET-1 in the blood of men and women were differently reflected. Cl was lower in hypertensive patients than in the control groups, indicating the predominance of vasoconstrictor concentration compared with healthy individuals. CNP/ET-1 index can be used to diagnose hypertension.