Serum lipid profiles in patients with metabolic syndrome with or without coronary artery disease

Abstract

The purpose of study: To assess serum lipid profiles in patients with metabolic syndrome (MS) and stable angina pectoris (SAP) vs. patients with MS without SAP. Material and methods: This study included 122 patients with metabolic syndrome (mean age 54.06 ± 0.86 years). The diagnosis of MS was established according to criteria proposed by IDF and AHA/NHLBT in 2009. All patients with MS and clinical signs of SAP undergo bicycle exercise stress test (EST), unless contraindicated. Depending on EST results, there were selected 66 (54.09%) patients with SAP and positive EST (group I) and 56 (45.9%) patients with negative EST (group II, control). Following evaluation included laboratory investigations: total cholesterol (TC), LDL cholesterol (LDLC), HDL cholesterol (HDL-C), triglycerides (TG) and TC/HDL-C ratio > 4,2in both groups. Results: Lipid profile assessment revealed that the mean value of TC for patients in group I was 5.63 ± 0.14 mmol/1 vs. 5.42 ± 0 .1 5 mmol/1 for patients in group II (p>0.05). The mean LDL-C in group I patients was 3.46 ±0.11 mmol/1 vs. 3.25 ± 0 .1 3 mmol/1 in group II patients (p<0.05). In group I patients we estimate a mean HDL-C value of 1.23 ± 0.04 mmol/1 vs. 1.27 ± 0.04 mmol/1 in group II patients (p>0.05). As for TG findings, the average value was 2.22 ± 0.1 mmol/1 in group I patients vs. 1.95 ± 0 .1 3 mmol/1 in group II patients (p>0.05). When considering the frequency of dyslipidemia, we found TC values >4.5 mmol/1 in 59 patients (95.16 %) from group I vs. 46 patients (82.14% ) from group II (p<0.05). Values of LDL-C > 2.5 mmol/1 were found in 48 patients (87.27%) from group I vs. 44 patients (78.57%) from group II (p >0.05). Analysis of TG levels >1.7 mmol/1 revealed significant higher rates of hypertriglyceridemia in group I patients (82.26%, n=51) vs. group II patients (48.21 %, m=27) (p<0.001). HDL-C assessment demonstrated values <1.0 mmol/1 in men and <1.3 mmol/1 in women in 22 patients (36.02%) with MS and SAP and 28 patients (50.0%), MS without SAP (p >0.05). Also an increased atherogenic index, as determined by the ratio of TC / HDL-C, was proven in both groups (group I - 4.7 ± 0 .1 7 vs. group II - 4.3 ± 0.12, p >0.05). In group I we determined values of TC/HDL-C ratio >4.2 in 36 patients (58.06%) vs. 23 patients (41.07%) in group II (p>0.05). Conclusion: In both groups of patients we determined abnormal lipid profiles. To be also mentioned the presence of a larger number of patients with TC and TG values exceeding the allowable limits in the group with metabolic syndrome and stable angina pectoris.