The course of coronary heart disease at different oxygen saturation

Abstract

Introduction: In industrialized countries, as well as in Ukraine, coronary heart disease (CHD) is one of the most common diseases, which ranks first place among causes of death. Equally important is the problem of chronic obstructive pulmonary diseases (COPD), which is the fourth most significant cause of death among .Ukrainian population. The simultaneous presence of COPD and coronary artery disease leads to a syndrome of “mutual burden.” Aims: The aim of our research is to study CHD flow rate depending on the saturation of oxygen. Methods end results: We examined 20 male patients aged from 47 to 72 years with coronary heart disease with postinfarction cardiosclerosis. The first group consisted of 12 patients with CHD without concomitant pulmonary disease, the second group - 8 patients with coronary heart disease with concomitant COPD. The level of oxygen saturation has been measured by pulse oximeter “UTAS oxy-201.” In the first group, the average blood oxygen saturation is 97 ±0,18, and patients of the second group - 93 ± 0,39%. Among patients of the second group the majority of men was smokers and smoked about a pack of cigarettes every day. In this group of patients has been noticed heavier disease that manifested itself in deterioration of patients, frequent instability of angina. It is known that metabolic disturbances in cardiac muscle are dependent on many factors, including: arterial blood oxygen saturation, myocardial extraction of oxygen, coronary blood flow, in the cross diameter of coronary arteries, arterial tone, presence of atherosclerotic plaque and coronary vasoconstriction. This group has found a direct correlation between oxygen saturation and such data, as hemoglobin (r = 0,51; p <0,05) and erythrocytes (r = 0,34; p <0,05.), which confirms the combined effect of coronary, ventilation and hemic hypoxia on the myocardium. Also, it has been revealed a tendency of sodium increase in plasma of second group patients (r = 0,40; p <0.05), which may confirm renal dysfunction in these patients. Conclusion: Reduced oxygen saturation in patients with coronary artery disease with concomitant COPD leads to increased myocardial ischemia with possible destabilization of angina.