Relations: endogenous intoxication syndrome-oxiredox and nitric oxide

Abstract

Introduction: Key indicators in the pathogenesis of acute pancreatitis are: trypsin, chymotrypsin, elastase, kallikrein, nitric oxide. Purpose: Determining the role of oxiredox system and NO in establishing endogenous intoxication syndrome in children with acute pancreatitis Materials andmethods: It was done astudy in PMSISCM “V. Ignatenco” in the pediatric gastroenterology department and included 100 patients. Children were divided into the following groups: first group, healthy children-20, II-group 40 children with acute pancreatitis during the onset, third group of 30 children who received standard therapy and BowelGuna, and fourth group of 30 children who received standard therapy. Treatment duration was one month. Results and discussions: The highest values of early HPL were recorded in studied patients from group 11-16,76±0,29uc/ml(p<0,001). Intermediate HPL-hexane, was registered at the maximum values in children with acute pancreatitis study group II who received Guna Bowel on the first day and constituted 5,27±0,15uc/ml with a return to normal limits 4,81±0,17 uc/ml a month. MDA values were observed in large amounts in children from study group II18,96±0,99uc/ml with subsequent decrease in value soverone month after treatment with Guna Bowel 17,14±0,47uc/ml. Nitric oxide was observed in study group IV patients(81,39±3,98m/l) compared with healthy children(78,7±2,85m/l). In children from study group III - obvious reduction of nitric oxide up to 74,67±6,34 m/1 was revealed. In patients with acute pancreatitis, increased concentration of middle moleculesup to 22,58±l,77m/land returned to normal 14,66±0,6m/l after treatment with GunaBowel. The level of necrotic substances was determined at maximal values in study group II2,28±0,17u/c with are turn to normal after treatment with Guna Bowel for l month (l,46±0,07u/c). Conclusions: 1.Endogenous intoxication syndrome in children with acute pancreatitisis characterized biologically by increasing concentration of average molecules at the onset of the disease to 22,58± l,77u/c and return to normal indices over amonth of standard treatment and inclusion in regimen after the onset of acute pancreatitis of Bowel Guna; 2. Therefore, the realized study confirms the direct correlation between lipid peroxidation indicesHPL, DAM) and endogenous intoxication syndrome values (average molecule, necroticsubstances). Coloring directly was determined from AAT, NOand the level of HPL, DAM, mediamolecule, necroticsubstances, which confirms the depletion of compensatory processesand implementation of the inflammatory process in the pancreatic gland.