Abstract:
Introduction: The number of patients with gynecological problems is increasing constantly. Two
common problems in this area are dysmenorrhea and threatened abortion. Dysmenorrhea is one of the
most common gynecologic complaints in young women who present to clinicians.
Material and Methods: Dysmenorrhoea affects nearly 50% of women capable of reproducing and
occurs more frequently among those aged between 15 and 25 years, approximately 10% of these being actually in a state of physical disability for a few days. Threatened abortion is a condition that occurs during the first 20 weeks of pregnancy, in which vaginal bleeding suggests an increased risk of miscarriage.
Vaginal bleeding is common in early pregnancy. About 1 of every 4 pregnant women has some bleeding
during the first few months. About half of these women stop bleeding and have a normal pregnancy. It
is necessary to develop a pharmaceutical form of local action. One of the procedures often used in gynecology is the procedure of relaxation and dilation of the uterus.
Substance that can be used in this case is papaverine hydrochloride. Papaverine relaxes various
smooth muscles. This relaxation may be prominent if spasm exists. The muscle cell is not paralyzed by
papaverine and still responds to drugs and other stimuli causing contraction. The antispasmodic effect is
a direct one, and unrelated to muscle innervations.
Results: Purpose of this work was to obtain and research cervical osmotic systems with papaverine
hydrochloride. In the experimental part we created the technology of preparation, we determined the
availability of pharmaceutical “in vitro” and we developed the pharmacopoeia monograph.
Conclusions: In this study we have analyzed three types, with different components of the recipients.
The results obtained have chosen based on form, which have the best availability and if all three forms
correspond to pharmacopoeial following parameters: description, identification, average weight and uniformity of mass, time of complete deformation, dosage.
