Institutional Repository in Medical Sciences
(IRMS – Nicolae Testemițanu SUMPh)

Distribution of the CCR5 ∆32 mutation in population groups in Romania

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dc.contributor.author Farcas, Marius Florin
dc.date.accessioned 2022-02-11T09:19:22Z
dc.date.available 2022-02-11T09:19:22Z
dc.date.issued 2012
dc.identifier.citation FARCAS, Marius Florin. Distribution of the CCR5 ∆32 mutation in population groups in Romania. In: MedEspera: the 4th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2012, pp. 37-38. en_US
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/20095
dc.description.abstract Introduction: The CCR5 gene encodes a chemokine receptor used by HIV-1 to gain entry into CD4+ T cells. The CCR5 ∆32 mutation is a 32 base pair deletion that confers resistance against HIV-1 by introducing a premature stop codon and thus abolishing the receptor. The allelic frequency of this mutation in European populations is on average 10%, while in Indian groups the average frequency is 1%. Methods: By means of molecular genetics techniques, respectively PCR-Simplex (Polymerase Chain Reaction-Simplex), we investigated the genotype and allelic distribution of the CCR5 ∆32 mutation in two study groups from Romania, one consisting of 166 Romanian healthy individuals and the other of 133 healthy Roma ethnics. Results: In the Romanian population group we found 144 wild-type homozygous subjects, 21 heterozygous subjects and one subject which was homozygous for the A32 allele, while in the Roma ethnic group 111 subjects were wild-type homozygous and 22 heterozygous. The observed allele frequencies for the ∆32 mutation in the two study groups were 7% in the Romanian population group, respectively 8.3% in the Roma ethnics. Conclusions: This is the first study performed on populations groups from Romania concerning the distribution of the CCR5 ∆32 mutation. At the present moment there is not a single clear explanation to why such a high frequency of the CCR5 ∆32 mutation is found in Roma ethnics and while genetic drift, population mixture, or a specific founder effect can explain in part this required to elucidate the matter. en_US
dc.language.iso en en_US
dc.publisher State Medical and Pharmaceutical University Nicolae Testemitanu, Medical Students and Residents Association, Scientific Association of Students and Young Doctors en_US
dc.relation.ispartof MedEspera: The 4th International Medical Congress for Students and Young Doctors, May 17-19, 2012, Chisinau, Republic of Moldova en_US
dc.subject heterozygous subjects en_US
dc.subject chemokine receptor en_US
dc.title Distribution of the CCR5 ∆32 mutation in population groups in Romania en_US
dc.type Other en_US


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  • MedEspera 2012
    The 4th International Medical Congress for Students and Young Doctors, May 17-19, 2012

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