Acute toxicity of profetur and metiferon

Abstract

Was studied the acute toxicity of substances metiferon and profetur by intraperitoneal administration in rats and mice. Preparations were introduced in different doses to determine the maximum tolerated dose and lethal absolute dose. At high doses of profetur animals became inhibited, apathetic, didn't react to stimuli audible and tactile intensity initially moderate and then high, caused tonic seizures. At high doses of metiferon, animals showed signs of peritoneal irritation, aggression, high excitability, tonic seizures, and stereotyped movements. Median lethal dose (LD50) determination was made according to the method of Kerber. LD50 of profetur is 630 mg/kg for mice. LD50 of metiferon is 520 mg/kg for mice and 480 mg/kg for rats.