Isothioureic-benzyturon derivative with hypotensive action

Abstract

Benzyturon substance was used in the experimental study in dose of 2 mg/kg dissolved in 1,5 ml fiziological solution, which was administrated intravenously to 11 normotensive cats, with weight 2-4 kg, anestesiated with urethane solution of 30% (lg/kg), administrated intraperitoneal, and subsequent with monitorization of blood pressure, the frequency of heart contraction and breath, at different intervals of time during 7hours. Initially, the blood pressure was 135 mmHg, the frequency of heart contractions (FHC) -157,2 beats/minute, breathe -96,9 breaths/minute. After administration of benzyturon substance the level of blood pressure was reduced and frequency of heart contractions compensatory increased. The results after administration of medication at various time intervals were the following:on 2 minutes with -7,1% and +9,6%; on 15 minutes with -10,3 and +20,2%; on 30 minutes with -17,1% and +19,1%; on 60 minutes with -21,8% and +18,7%; on 120-240 minutes, reduced blood pressure was stable with -29,4 and the frequency of heart contraction remain in initial limits; at 300-360 minutes was found a maximum hypotensive effect of -38,9%, return to the initial levelto the 6th hours the same FHC . Breath initially shows a tendency to tachypnea to over 30 minutes,which reaches over 2 hours the initial fissures following that and then to shrink over 5 hours till the minut values (54,7 +/- 7,6 compared with 96,6+/- 7,8; 1<0,05). Isothioureic-benzyturon derivative shows marked hypotensive action, slow and long with maximum effect and stable between 2-7 hours after administration, with a moderate reflectory tachycardia.