Abstract:
Introduction: According to the World Health Organization, about 15 million people suffer stroke
worldwide each year. Of these, up to 87%, are ischemic strokes. Internal carotid artery (ICA) stenosis is
one of the most important risk factor, producing 30% of all ischemic strokes. Estimates indicate that 5
per 1,000 persons aged 50-60 years and approximately 10% of persons older than 80 years have carotid
stenosis greater than 50%. We consider it an important aspect, which will help better understand the
mechanism of stroke.
Purpose: To find out the most common neurological manifestations, in patients with internal carotid
artery stenosis, who had an ischemic stroke.
To elaborate a plan of prevention and diminish the number of visits to doctors, due to early neurological manifestations predicting an ischemic stroke, or its relapse;
• To determine major rise factors leading to those manifestations;
• To detect the features of early neurological manifestations in patients with different degree of
internal carotid artery stenosis;
Material and methods: 100 patients who had an ischemic stroke (50 patients with internal carotid
artery(ICA) stenosis, and 50 in the control group, without ICA stenosis);
The comparative analysis of case histories, neurological manifestations, CT scans, clinical and imaging investigations, together with statistic analysis has been performed.
Results: We found that 88% of patients with a critical ICA stenosis and ICA occlusion, had smaller
ischemic areas on CT than patients in the control group and patients with smaller ICA stenosis; 71,5%
of them also had longer - lusting and more numerous clinical manifestations than patients in the control group. We have also compared their „border” cerebral tissue resistance to ischemia, documented by
the presence of “Watershed” phenomenon (an area of necrosis in the brain caused by an insufficiency of
blood where the distribution of cerebral arteries overlap, in which the most distant areas may not receive
blood supply, if there is a fall in circulation) in 36% of patients with ICA stenosis, and 26% in patients in
the control group. The analysis of the type of plaque, the role of risk factors, the influence of coagulation
factors, and patients’ reabilitation performances, has also been included in this study.
Conclusions: We have demonstrated clinically, that patients with ICA stenosis, have more prolonged
and numerous clinical manifestations than patients in the control group, they manifest better imaging
results, and a more frequent “border” necrosis, which can give us premises to help overcome ischemic
stroke and its consequences.
