Abstract:
Introduction. Numerous studies have shown the
susceptibility of pancreatic tissue to alcohol consumption,
exerted by various mechanisms, including the induction of
oxidative stress.
Purpose: Evaluation of antioxidant system indices in
patients with chronic pancreatitis according to the duration of
alcohol consumption.
Material and methods: The study included 100 patients
with chronic pancreatitis, men/women -55%/ /45%, mean age -
47 ± 0.93 years (19-59 years). Clinical and paraclinical changes
specific to chronic pancreatitis were evaluated according to the
recommendations of the European Society of Gastroenterology.
Informed agreement was obtained from all patients. Indicators
of the antioxidant system (ODS) assessed in venous blood:
Total Antioxidant Activity (AAT) - in the hexane (hexane) and
isopropanol (isopr.) phases, Superoxidismutase (SOD),
Catalase, Glutadionreductase (GR).
Results: Alcohol consumption was confirmed in 55 patients: in 3 patients ≤ 10
years, in 16 10-20 years, in 27 20-30 years, in 9 >30 years. Increasing the
duration of alcohol use from ≤10 years to > 30 years was identified: decrease in
SOD activity (c/u) from 1395.45±47.51 to 1141.10±.61, F=3.51, p<0.05, Catalase
(M /s.l) from 9.84±0.24 to 7.95±1.07, F=4.51, p<0.05; AAT-hexan. (mMDPPH/l)
from 8.62 ± 0.82 to 6.80 ± 0.49, F=3.53, p<0.05.
Conclusion: Prolonged alcohol consumption affects the pancreatic tissue
through various mechanisms, as a result there is an induction of oxidative stress,
manifested by decreased activity of antioxidant system indices.
