Abstract:
Introduction. Despite numerous clinical studies on the frequency,
pathogenetic mechanisms and clinical characteristics of
axial spondyloarthritis (SpAx) in infectious bowel diseases
(IBD) and intestinal damage in ankylosing spondylitis
(SA), there are currently a number of unresolved problems,
especially the problem of early diagnosis of arthropathies.
Purpose. Determination of peculiarities of early manifestations of
axial arthropathies in IBD to improve early diagnosis and
identify clinical variants with the development of algorithm
for the early detection of SpAax in IBD.
Material and methods. During the years 2015-2021, 141 patients were examined, of
which 50 patients with SA and 91 patients with IBD from
the Republican Clinical Hospital "Timofei Moşneaga”. According to the mediation of the inflammatory response
patients with IBD were divided into 2 groups: the first -
Yersinia enterocolitica or Campylobacter jejuni (Y±C) , the
second - Salmonella enteritidis or Shigella flexneri (S±Sh).
Results. In patients with IBD, the following clinical variants of
arthropathies have been identified: SpAax - 28,6%, SA -
15,4%; arthralgia - 38.5%, arthritis - 13.2%. Conventional
radiography and MRI of SI joints increased the incidence of
SpA from 6.6% to 28.6%. In patients with IBD and axial
arthropathies, arthralgia, arthritis and uveitis were the frequent
manifestations and the possibility of detecting axSpA was
higher in the presence of arthritis.
Conclusions.Our study allowed us to establish the parameters and the
diagnosis of (S±Sh), in the presence of which special
attention should be paid to patients with IBD in case of
suspicion of SpA.
