Abstract:
Introduction: Research on the relationship between the
human microbiome and malignant tumors has received
particular interest in recent years.
Material and methods 26 saliva and oral buffer samples
were analyzed from patients with HNSCC by quantitative
PCR method for 7 periodontal pathogens: Porphyromonas
endodontalis, Porphyromonas gingivalis, Aggregatibacter
actinomycetemcomitans, Treponema denticola,
Fusobacterium nucleatum, Prevotella intermedia
and Tannerella forsythia.
Purpose of the study was to determine the concentration
of periodontal pathogens in the oral microbiome in
patients with HNSCC.
Results show F. nucleatum exceeds the norm in 20
samples (19 smokers and 1 non-smoker) and T. forsythia
in 18. P. endodontalis was identified in all patients with
laryngeal carcinoma and approx. in 30% of patients with
carcinoma of the lip and oropharynx.
Conclusions Of all the 7 species studied, F.
nucleatum and T. forsythia have pathological
concentrations in most samples.
