Abstract:
Introduction. The endothelium is a crucial regulator of vascular homeostasis lupusassociated chronic systemic inflammation may compromi se endothelial functioning triggering a chain of events that when combined with established CVD risk factors leads to the formation and progression of atherosclerosis. Purpose. To asses how SLE affect the function of endothelium. Material and methods. We have performed a database search of all relevant literature published until June The search included English written articles Electronic databases including PubMed Oxford Academics Google Scholar were searched using the following terms: ”SLE+endothelium dysfunction”.
Results.
The search yielded articles out of which
articles were considered relevant published from
to Out of articles were literature
reviews and cross sectional and case control
studies including a total number of SLE
patients To date the vast majority of available
data albeit not all indicates that endothelium
dependent FMD values are lower in SLE patients
compared to healthy subjects Notably FMD
variations can be used to assess certain therapy
methods capacity to improve endothelial function
in SLE patients.
Conclusions.
Endothelial function appears to be affected by SLE
potentially contributing to the increased
cardiovascular risk observed in SLE patients.
