Abstract:
Introduction.
The Republic of Moldova perceives a major impact
on public health caused by mental health disorders,
prevalence-2.468/100.000, and the rate of mental
disorders among tuberculosis (TB) patients was 5%
in 2017.
Purpose.
To assess the risk factors for pulmonary TB in
patients with mental in health disorders.
Material and methods.
A retrospective case-control study was performed consisting from
study group (SG) of 71 patients with pulmonary TB and mental
pathologies diagnosed during 2015-2020 and control group (CG) of
185 cases of pulmonary TB without mental disorders diagnosed in
2019 in Chisinau.
Results.
Male/female ratio=5/1 in SG vs 3/1 in CG, between 18-45 years
24(34%) vs 102(55%), over 45 years 47(66%) vs 83(45%) , (p<0,001).
Risk factors were: male sex OR=3.1 (CI95%: 1.6-5.2), age over 45 years
OR=3.4 (CI95%: 1.2-7.8), unemployment OR=6.8 (CI95%: 1.9-19),
absence of health insurance OR=3.2 (CI95%: 2.1-5.1), homelessness
OR=5.7 (CI95%: 3.2- 8.2), HIV+ status OR=2.7 (95% CI: 1.1-3.2),
microscopic (+) for AFB were 27 (38%) vs 95 (51%) and culture (+)
were 32 (45%) vs 102 (55%). Were successfully treated 37 (52%) vs
152 (82%), died 20 (28%) vs 16 (9%), failed or were lost to follow-up
were 14 (20%) vs 17 (9%) cases.
Conclusion. The risk factors for TB in patients with mental health
disorders were male sex, age over 45, socio-vulnerable status which
had negative impact on the treatment efficacy.
