Abstract:
Abstract
Introduction. Hematological inflammatory markers
may be promising diagnostic markers for assessing the severity of intrahepatic cholestasis of pregnancy. The aim of
the study was to evaluate and compare the levels of hematological inflammatory markers in intrahepatic cholestasis
of pregnancy.
Material and methods. A prospective cohort study of
142 clinical cases, divided into two groups depending on
the presence of cholestasis gravidarum, was carried out.
The research was conducted by assessing the level of bile
acids and hematological inflammatory markers in the mother’s blood, as well as by studying medical records. The IBM
Statistics SPSS 21 program was used to process the statistical data. To compare categorical variables, the χ² without
the Yates’ continuity correction test was applied.
Results. There was an increase in platelet-to-lymphocyte ratio in pregnant women with intrahepatic cholestasis
of pregnancy compared to the control group (146.0±6.8
versus 135.2±7.3, respectively). The values of neutrophil-to-lymphocyte ratio and the average volume of platelets were similar in both groups. At the same time, the study
found a decrease in the values of erythrocyte distribution
among women whose pregnancy was complicated by
cholestasis gravidarum.
Conclusions. The study showed a significant increase
in platelet-to-lymphocyte ratio in women whose pregnancy
was complicated by cholestasis gravidarum, as well as an
increase in this indicator with increasing levels of bile acids. Thus, this ratio may be a promising diagnostic marker
in assessing the severity of intrahepatic cholestasis of pregnancy.
