Abstract:
Summary.
Introduction. Prostatitis is an inflammatory process of
the prostate, which continues to be considered one of the
most common urological diseases in men under 45. Predisposing factors such as trophic, microcirculatory, and congestive disorders contribute to the onset and development
of the inflammatory process in the prostate, as do risk factors such as the urethral catheter, urethrocystoscopy, endoscopic surgery for infection, and deterioration of the integrity of the urethral epithelium. The purpose of this study
was to determine the impact of chronic inflammation and
fibrosis of the prostate on urodynamics and local prostatic
microcirculation and to evaluate the efficacy of conservative
treatment.
Material and methods. The study included 58 patients
(with pronounced clinical symptoms such as dysuria, stranguria, nocturnal frequent micturition 2-4 times per night,
and residual urine greater than 50 mL) who received Adenosprosine® 250 mg treatment.
Results. A comparative study of the obtained data was
performed on the pre- and post- treatment investigations
with Adenoprosine® 250 mg suppositories, thus determining the correlation between urodynamic and microcirculation disorders depending on the degree of inflammation
and prostate fibrosis.
Conclusion. According to the study results, we can outline that the level of microcirculation and urodynamic impairment indicates the level of prostate fibrosis. This process is reversible in chronic prostatitis with antifibrotic and
anti-inflammatory therapy supplemented with Adenoprosine® 250 mg.
