Abstract:
Introduction. One of the promising methods of treatment of patients with burns is the local use
of sorption agents with antimicrobial properties.
Objective of the study. Studying the antimicrobial properties and clinical effectiveness
evaluation of the local use of a new sorption composition based on nanosilica in the complex
treatment of patients with burns.
Material andMethods. The suggested sorption nanocomposition included highly dispersed
silicon dioxide, polymethylsiloxane, decamethoxine, metronidazole. The experimental study
evaluated the antimicrobial properties of the sorption nanocomposition and antimicrobial agents
which are part of it. 42 patients with IIab-III degree burns with an area of 10-30% of the body
surface were examinated. Depending on the tactics of local treatment, patients were divided into
2 groups: after early necrectomy, xenodermoplasty, the wound surface of the patients in the main
group (n = 20) was treated with a solution of decamethoxine in combination with the same
sorption powder. Treatment in the control group (n = 22) was similar except the use of sorption
drugs. The examination included visual inspection of the injured area in combination with
microbiological monitoring of the wound contents on the 3rd,7th,14th day.
Results. The obtained results confirmed the sufficient antimicrobial potential of the studied
sorption nanocomposition, the properties of which are on the equal foot with the existing
antiseptics applied for museum and clinical strains of microorganisms and fungi. Signs of a more
favorable wound healing process of the patients in the main group were observed: faster wound
cleaning, less inflammatory reactions and much shorter preparation of wounds for grafting.
Conclusion. The obtained results convincingly show the effectiveness of a multicomponent
composite based on nanosilica with antimicrobial components in a comprehensive treatment of
patients with burns.
