Abstract:
Introduction. Organ and tissue transplantation can save lives or significantly improve the quality of
life. In order to organize the activity of taking and transplanting organs and tissues from the donor
to the recipient on the territory of the Republic of Moldova, the Law no. 42 of 03.06.2008
"Regarding the transplantation of organs, tissues and human cells" was adopted (published on
25.04.2008 in the Official Gazette, no. 81, art. no. 273, date of entry into force 25.10.2008) and
revised Law No. 42 on the transplantation of human organs, tissues and cells of 06.03.2020.
Objectives. Steps in sampling of organs and tissues from a "brain death" donor based on the
clinical case.
Materials and methods. Description of a clinical case about a patient hospitalized in the Municipal
Clinical Hospital “Saint Trinity”, Intensive Care department, 2022.
Results. A man, 67 years old, was hospitalized in extremely serious condition, from the anamnesis
(collected from relatives) - the patient had several comorbidities, including hypertension. The clinical
diagnosis: Ischemic stroke. Arterial hypertension grade III very high additional risk. Mixed cardiomyopathy (hypertensive, ischemic, dysmetabolic). Heart failure III NYHA. Despite the complex
treatment administered, "brain death" was found, which was confirmed according to the Standardized
Clinical Protocol. Following the discussion with the relatives, consent was received for the removal of
organs and tissues. The kidney transplant recipient was selected based on HLA typing, Cross-match,
pre-existing antibody titer, general condition and lack of contraindications for surgery. 2 kidneys,
liver, 2 corneas, 4 vessels were taken from the donor, but one kidney was not transplanted due to the
presence of suspicious lesions, after histopathological examination it was established: Atherosclerotic
nephropathy. Multiple renal infarcts. Atherosclerosis of the renal artery st. IV, degree II.
Conclusions. 1. In the given case, organ removal was possible after the consent of the donor's
relatives; 2. Organs, tissues and cells can be taken from the deceased person only if the death has
been confirmed according to the criteria established by the Standardized Clinical Protocol (which
were confirmed in this case); 3. Following investigations and complex compatibility tests, a patient
with liver failure and another with end-stage renal failure were transplanted, other tissues taken
(cornea-no.2, vessels-no.4) were processed and stored at the Bank of tissues.
