1. COLECȚIA INSTITUȚIONALĂ: Recent submissions

  • The role of cardiac fibrosis in diastolic heart dysfunction 
    Semionov, Marius (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Cardiac diastolic dysfunction (DD) represents globally one of the main causes for congestive cardiac failure, occurring in 1/3 of reported cases. DD is most commonly a consequence of systemic arterial ...
  • The role of NO and H2S in circulatory homeostasis regulation and dysfunction 
    Eremia, Alexandru (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Modern concept corroborates vascular endothelium as a crucial pillar regarding the control of a lot of vascular derived functions in circulatory homeostasis, such as: basal vascular tone and blood pressure, ...
  • Pathogenesis of sexual dysfunction 
    Azar, Fadi (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. This text discusses the prevalence and impact of sexual dysfunction, including issues like erectile dysfunction, orgasmic disorders, delayed ejaculation, premature ejaculation, and sexual pain disorders. Aim ...
  • Morphopathology significance in detection and differential diagnosis of gastritis 
    Stoica, Tatiana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The term Gastritis in morphopathology is used to describe the inflammation of gastric mucosa. Ordinarily gastritis is associated with Helicobacter Pylori which is positive in 85 % of patients, other cases of ...
  • Advancing Parkinson's disease management: novel strategies and therapeutic innovations 
    Budianu, Cătălina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Parkinson's disease is a long-term neurodegenerative condition of the central nervous system that mainly affects the control of voluntary movements due to the gradual degeneration of dopaminergic neurons ...
  • Contemporary approaches to the treatment of frontotemporal dementia 
    Iarovoi, Alexandru (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Frontotemporal dementia or FTD relates to a group of diseases that are caused by neuronal degeneration. FTD is mainly of genetic etiology, due to mutations occurring in specific genes, and may be transmitted ...
  • Mesenchymal stem cell-derived exosomes and their antineoplastic potential 
    Louka, George (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Mesenchymal stem cells (MSC) are pluripotent cell types derived from mesenchyme able to differentiate and proliferate into a variety of tissues. Exosomes derived from MSC exhibit a round morphology (40-160 ...
  • Gene therapy for adenosine deaminase severe combined immunodeficiency (ADA-SCID) 
    Bogdanov, Alan (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. About 1 in 500,000 people are born with severe combined immunodeficiency (SCID). The adenosine deaminase variant is a fatal inborn error of purine metabolism. Accumulation of adenosine and deoxyadenosine ...
  • Combination of beta-blockers with ace inhibitors in the treatment of hypertension in patients with cardiac comorbidities 
    Ticlenco, Teodorina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Approximately 1.28 billion people worldwide are estimated to have hypertension, and it can either promote or accompany other cardiac comorbidities. The combination of betablockers with angiotensin-converting ...
  • Mechanisms of drug-induced nephrotoxicity 
    Iapara, Olga (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Drug-induced nephrotoxicity or drug-induced renal disease (DRID) is a common clinical problem. It has been reported that the incidence of drug-induced renal disease in adults can range from 14-26% to 66% ...
  • Drugs of choice in hypertensive emergency associated with acute aortic dissection 
    Prijilevschi, Cristina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Acute aortic dissection is a hypertensive emergency that requires an immediate reduction of blood pressure (BP) by administering intravenous drug therapy. Diligent control of BP is the most crucial in order ...
  • Acute drug intoxication - a modern look at old problem 
    Zveaghintev, Piotr (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Acute drug intoxication is a persistent and critical problem in the modern healthcare landscape. Study of the problem in recent years has marked an increase in the incidence of acute poisoning. Given the ...
  • Dapagliflozin as an SGLT2 inhibitor and its effect on the treatment of type 2 diabetes 
    Minchevici, Delia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Sodium-glucose cotransporter 2 (SGLT2) inhibitors represent a drug class commonly used in the management of type 2 diabetes. Aim of study. Dapagliflozin demonstrated a significant decrease in the occurrence ...
  • Gestational diabetes mellitus and macrosomia: municipal clinical hospital ”Gheorghe Paladi” experience 
    Micinschi, Nadina; Catrinici, Rodica; Baxan, Alexandra (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Gestational diabetes mellitus (GDM) is a metabolic complication during pregnancy. It is defined by the development of glucose intolerance, primarily diagnosed in pregnancy. According to literature between ...
  • New concepts of treatment of carpal tunnel syndrome 
    Lungu, Maria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Carpal tunnel syndrome is the most common form of focal peripheral compressive mononeuropathy of the median nerve accompanied by pain, paresthesia, weakness along the nerve's path and represents approximately ...
  • Pharmacological approach to Wernicke-Korsakoff syndrome 
    Cernov, Ecaterina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Wernicke-Korsakoff Syndrome (WKS) represents, in 16-38% of cases, a clinical triad of confusion, ataxia and nystagmus. Conceptualized as two distinct syndromes, 85% of survivors of the untreated acute phase ...
  • Particularities of the action of the inhibitors of the renin-angiotensin-aldosterone system in men and women 
    Nicolenco, Nicoleta (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The renin-angiotensin-aldosterone system (RAAS) plays a significant role in cardiovascular pathology, including arterial hypertension (HTA). It has been demonstrated that endogenous sex hormones interact ...
  • Morphological and immunohistochemical features in the differential diagnosis of hydatiform mole 
    Rusnac, Ioana Maria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Hydatidiform mole is a pathological pregnancy that belongs to the gestational trophoblastic diseases group. During histomorphological lesion examination, differentiating between molar and non-molar lesions ...
  • Significance of circadian rhythm for cardiac homeostasis 
    El Alamy, Hamdy (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Circadian rhythm plays a crucial role in the homeostasis of the cardiovascular system through hormonal secretion and the regulation of the nervous system's activity. Aim of study. This research aims to ...
  • The influence of circadian rhythms in the exacerbation of bronchial asthma 
    Mardari, Cristina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Asthma is an inflammatory disease of the airways, affecting 334 million people globally, of whom 44-61% are prone to developing complications during the night. One of the most important diagnostic criteria ...

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