1. COLECȚIA INSTITUȚIONALĂ: Recent submissions

  • The effects of strogens on brain plasticity 
    Brînza, Gabriela (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Estrogens have efects not only on gonads but also on the hippocampus and the prefrontal cortex area. The fluctuations of estrogen levels can directly influence cognitive functions, an important point in ...
  • Vitamin D (Vit. D) and diseases associated with its metabolism 
    Tighineanu, Nicoleta-Ionica (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Both the Vit.D receptor (VDR) and the enzymes that metabolize this vitamin are found in various cells, different from those involved in the homeostasis of calcium and phosphate, thus highlighting new aspects ...
  • Hypertensive emergencies between problems and achievements at the pre-hospital stage 
    Catanoi, Natalia; Rabovila, Ala; Scurtov, Natalia; Pestereanu, Mihail; Betisor, Vitalie (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. High blood pressure is a current medical, economic and social problem, due to a high incidence in the population and the major risks involved. It is one of the most common cardiovascular diseases and remains ...
  • Surgical approach in chest wounds with cardiac injury – report of 41 cases 
    Malcova, Tatiana; Gurghiș, Radu; Gagauz, Ion (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Cardiac injuries (CIs) are an important case of mortality, survival rates ranging from 19% to 74% in specialized institutions. Objective of the study. Evaluation of treatment results in patients with heart ...
  • The role of diabetes mellitus in association with pulmonary tuberculosis 
    Gamaniuc, Marina; Vișnevschi, Anatolie; Veselovskaia, Ana (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Diabetes mellitus (DM) is a major risk factor for the development of pulmonary tuberculosis. Overall, approximately 15% of pulmonary TB cases are associated with diabetes. Patients with diabetes associated ...
  • The importance of molecular diagnostics in allergology 
    Caraciobanu, Alina; Merean, Adriana; Brocovschii, Victoria (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Molecular diagnostic represents a new era in allergology. The allergic potential of allergenic molecules can be from minor local reactions, to systemic manifestations. Molecular diagnostic methods are based ...
  • New theories in migraine pathophysiology 
    Chitoroagă, Mihaela (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Migraine is the third most prevalent disease in the world and affects 12% of the general population. It has recently been suggested that central neurochemical imbalance and low 5-HT levels facilitate the ...
  • Secondary acute promielocytic leukemia developed after treatment of non-Hodgkin's lymphoma, case study and review of literature 
    Tomacinschii, Victor; Robu, Maria; Musteață, Vasile; Mocanu, Irina; Sporîș, Natalia; Feghiu, Veronica (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Acute promyelocytic leukemia (APL) is an acute myeloid leukemia (AML) that accounts approximately 10-15% of AML cases. APL usually appears as an de novo finding. The occurrence of secondary APL(sAPL) after ...
  • Liver damage in patients with COVID 19 infection 
    Veselovskaia, Ana; Gamaniuc, Marina (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. In December 2019, a novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in the Chinese province of Wuhan and rapidly infected hundreds of thousands of people worldwide. ...
  • Hepatotoxicity of fat-soluble vitamins A and E 
    Vasilache, Eugenia; Caracaş, Anastasia (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. The share of drug-induced liver diseases, caused by fat-soluble vitamins used uncontrollably, varies from 2 to 20 percent. Vitamins A and E, along with the beneficial effects, can exert toxic action on the ...
  • The role of major histocompatibility complex molecules in the immune system 
    Pricop, Ana (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. The major histocompatibility complex (MCH) is one of the most studied regions of the human genome. MHC is located on the short arm of chromosome 6 and plays an important role in susceptibility to several human ...
  • The evolution of the diagnosis of congenital neutropenias in the era of molecular technologies 
    Tomacinschii, Victor; Tomacinschii, Cristina; Robu, Maria (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Congenital neutropenias (CN) constitute a group of rare genetic disorders characterized by: severe recurrent infections secondary to neutropenia, various organic dysfunctions and a high risk of leukemic ...
  • Features of pulmonary function in interstitial lung diseases 
    Calaraș, Diana; Rusu, Doina; David, Aliona; Botnaru, Victor (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Interstitial lung diseases (ILD) represent a group of disorders that are generally thought to share a common pattern of physiologic abnormality, characterized by a restrictive ventilatory defect and reduced ...
  • Role of hypoxia-inducible factor 1 (HIF1) in tumorigenesis 
    Potereanu, Diana (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Cancer is one of the leading causes of morbidity and mortality worldwide. Proliferation, development and resistance of cancer cells are due to a specific microenvironment in which hypoxia is one of the key ...
  • Definition of Wilson disease in terms of Leipzig score 
    Tocan, Mihaela; Tocan-Musteața, Alina (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Wilson Disease (WD) is an autosomal recessive disease caused by mutations in the ATP7B gene, which lead to the pathological accumulation of copper in the body.The Leipzig score (validated in 2001) is used to ...
  • The nictemeral blood pressure variability and intrarenal hemodynamics in patients with heart failure with preserved ejection fraction 
    Cabac-Pogorevici, Irina; Revenco, Valeriu (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. The prognostic impact of each determinant of blood pressure (BP) profile such as systolic BP, diastolic BP, pulse pressure (PP), BP variability (BPV) was essentially studied in patients with hypertension, but ...
  • Intermediate and low risc NSTEMI patients: immediate versus delayed reperfusion 
    Surev, Artiom; Abraș, Marcel; Grib, Andrei; Moiseeva, Anna (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. An immediate repefusion for treating high-risk NSTEMI patients is the gold standard. Treatment of intermediate to low risk patients is not always so straightforward. The rush to perform revascularization can ...
  • Intrarenal hemodynamics in arterial hypertension and heart failure with preserved ejection fraction 
    Cabac-Pogorevici, Irina; Mihalache, Georgeta; Ochisor, Viorica; Cojuhari, Inessa; Revenco, Valeriu (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Traditional cardiovascular risk factors in the general population are usually correlated with the prognosis in patients with heart failure with preserved ejection fraction (HFpEF). Objective of the study. The ...
  • The peculiarities of the evolution and treatment of chronic glometulonephritis 
    Struță, Alina; Rotaru, Larisa; Groppa, Liliana; Agachi, Svetlana; Pascal, Rodica; Răzlog, Tatiana (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Chronic glomerulonephritis develops gradually, can be detected occasionally in the absence of symptoms. The chronic type of the disease has no definite cause. Chronic glomerulonephritis is the cause of 35% ...
  • Multidimensional aspect of the elderly fragility 
    Șoric, Gabriela; Popescu, Ana; Cosciug, Elena; Popa, Ana; Negară, Anatolie; Bodrug, Nicolae (Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova, 2020)
    Background. Frailty is the geriatric syndrome, characterized by decreased physiological reserve and body functions associated with age leading to an increase in vulnerability and a negative impact on health - loss of ...

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