Abstract:
Introduction. Cholestatic jaundice installed in gallstones is considered a multifactorial pathogenetic process. The
correlation of endogenous hepatic intoxication with the reaction of the pro- and antioxidant system, characteristic of
various complications of gallstones associated with cholestatic jaundice, remains an undefined subject.
Material and methods. The study included the investigation of 105 patients with complicated gallstones and associated
cholestatic jaundice, and the control group – 35 patients with uncomplicated gallstones. The age of the patients varied
between 51 and 72 years, with an F/M ratio of 3/1.
Results. The degree of endotoxemia, assessed at hospitalization by peptides with average mass values, was consistent
with the inflammation present in groups 2 and 3, reporting a statistically significant difference compared to the control
group [p c/2 < 0.001 (t = 11.1); p c/3 < 0.001 (t = 11.07)]. DAM, as the final product of lipid peroxidation, evaluated at
hospitalization, shows double marked values in all groups compared to the control group [p < 0.001 (t = 10.7); (t = 10.9);
(t = 16.5)]. The antioxidant activity, assessed at hospitalization, shows a statistically significant decrease in superoxide
dismutase values [p < 0.001 (t = 6.4); (t = 4.1); (t = 5.7)], as well as catalase [p < 0.001 (t = 6.7); (t = 5.6); (t = 7.2)] in all
groups, by 30-40% compared to the control group.
Conclusions. In established cholestatic jaundice, there is an obvious activation of lipoperoxidation processes, contributing
to the increase of endogenous intoxication and early suppression of antioxidant activity. There is a direct relationship
between the increase in prooxidant activity and the level of endogenous intoxication in all complications of gallstones
associated with cholestatic jaundice, but it is more elevated in infectious complications, indicating a need for an early
approach.
