Abstract:
Background. The most common cause of lower limb ulcers is chronic venous insufficiency.Up to 48%
of patients with trophic ulcers are at the age of maximum productivity. 67% of patients with trophic
ulcers become disabled, and in 81% the quality of life decreases considerably. Injection of autologous
platelet-rich plasma (PRP) is an important factor in tissue regeneration and represents a new
perspective in the treatment of trophic ulcers.
Material and methods. Prospective study. The study included 28 patients, divided into 2 groups, with
trophic ulcers of the lower limbs with a duration of 6-24 months without epithelization dynamics,
paraclinically confirmed the presence of chronic venous insufficiency. I group 14 patients combined
treatment with PRF injection in venous ulcers. II control group – 14 patients who benefited from
general basic treatment and local compressive treatment. All patients were monitored for 1 year.
On the 7th and 14th day of treatment, histological examinations of trophic ulcers were performed in
both groups of patients, with a comparative evaluation of the results obtained.
Platelet-rich fibrin membranes were obtained by centrifuging under special conditions the peripheral
venous blood collected from the patient.
Results. In group I complete epithelialization after 12 months of treatment combined with platelet-rich
fibrin was obtained in 10 patients and in 4 patients incomplete epithelialization was obtained (70% of
the ulcerated surface) In group II control after 12 months of treatment epithelialization complete
epithelialization was obtained in 7 patients and incomplete epithelialization in 7 patients (40% of the
ulcerated surface)
The results of the histological examination demonstrated in Lot I the appearance of the neovascular
network with granulation tissue in all patients. In batch II, the lack of formation of the neovascular
network.
Conclusions. The use of autologous Platelet-Rich Fibrin is a simple and affordable method to use.
PRF membranes initiate and accelerate granulation tissue formation and angiogenesis. As a result,
complete epithelization of the ulcers occurs, improving the patients' quality of life.
