Abstract:
Background. Toxic osteomyelitis is an inflammatory origin pathology, which occurs in the jaws
following the consumption of drugs with a high content of phosphorus and ephedrine, following
treatment with bisphosphonates or radiotherapy. Its treatment is only surgical, it consists of
sequestrectomy and results in a lack of bone tissue in the oro-maxillo-facial region.
After the interventions, patients are left with obvious sequelae and a significant lack of bone. For the
rehabilitation of these patients, reconstructive surgery, orthopedic and prosthetic treatment,
physiotherapy and pharmacotherapy are used. The use of osteogenetic stem cells has proven to be
extremely effective, showing good results. A preparation that has demonstrated its effectiveness in
appropriate clinical cases is Osteostimulin-C, which is an example of allogeneic embryofetal
osteomedullary cells (CEFOMA).
Material and methods. The following study has been performed using the medical files of patients in
the post-sequestrectomy state of the jaws, for whose rehabilitation the Osteostimuln-C drug was used.
Results. After the recovery of the patients and the healing of the operative field, it was rehabilitated
by applying Osteostimulin-C. The success of this treatment allowed not only sufficient restoration of
the jaw bone, as prosthetic treatment was possible, but also played a significant antibacterial role.
Conclusion. The utilization of CEFOMA allows the treatment of acquired bone pathologies,
characterized by lack of continuity and bone substance via stimulating of new bone tissue growth,
which allows a faster rehabilitation and a better quality of life for the patient.
