Abstract:
Background. Alzheimer’s disease (AD), a progressive
neurodegenerative disorder, is characterized by cognitive
decline and memory loss. Recent research has claimed a
potential link between intestinal disorders and AD, suggesting that gut health may play a critical role in the onset
and progression of AD. Objective of the study. Assessment
of the potential links, mechanisms, and implications of gut
disorders in the pathogenesis and progression of AD. Material and methods. The 26 scientific papers and textbooks
from academic platforms as PubMed, Medline, Hinari, Google Scholar, Elsevier, Web of Science published in the last 10
years, were analyzed. Results. The findings suggest a significant association between gastrointestinal disorders and the
development of AD. Chronic inflammation such as inflammatory bowel disease and irritable bowel syndrome, with
elevated levels of pro-inflammatory cytokines and immune
system dysregulation may contribute to AD. Gut disorders
can impair nutrient absorption, leading to deficiencies in essential vitamins and minerals that support cognitive function. Malnutrition and deficiencies in vitamins such as B12
and D have been associated with an increased risk of AD.
Microbiome alterations can affect brain health through the
production of neuroactive compounds and modulation of
the immune system. Dysbiosis has been linked to increased
amyloid-beta deposition and tau pathology, hallmark features of AD. Disruption of the gut-brain axis due to gut disorders can lead to neuroinflammation and neurodegeneration. Conclusions. Multiple studies have demonstrated the
possible connection between gut conditions, which include
inflammation, nutrient absorption, microbiome status, the
involvement of the gut-brain axis in the development and
progression of AD. A deeper understanding of these mechanisms could open up new possibilities in the prevention and
more effective treatment of AD.
