Rolul determinativ a modificărilor structurale ale rinichilor la făt în cadrul inecției intrauterine

Abstract

In recent decades, neonatal nephrology has advanced thanks to prenatal ultrasound and clinico-morphological studies, wich have shown an increased incidence of pyelonephritis (PN) and other renal pathologies in newborns from pregnancies complicated by intrauterine infections. Congenital cytomegalovirus (CMV)affects the renat tubular ephitelium, where characteristic inclusions are observed. It is associated with chronic renal lesions. Congenital toxoplasmosis can cause congenital nephrotic syndrome, with immune deposits in the glomeruli. Zika virus infections impairs renal development, while associated factors such as chorioamnionitis, intrauterine growth restriction, and prematurity increase risk of proteinuria, hypertension, and chronic kidney disease. In the histopathological study, the kidneys of 81 newborns who died from intrauterine infections were examined. This study on morphopathological examination showed small glomeruli, enlarged boeman´s space, sclerosis, and interstitial nephritis. Intrauterine infections cause not only systemic damage but also congenital anomalies of the kidneys and urinary tract.