Abstract:
Gender incongruence is a condition marked by a persistent mismatch between assigned sex at birth and
experienced gender identity. It involves rejection of sexual traits, a strong desire to change them, and the need
to live as the identified gender, requiring support to ease distress and improve life quality. Analysis of the
effectiveness of psychological, hormonal, and surgical interventions, highlighting the differences between
monotherapy and combined approaches in treating gender incongruence. Analysis based on: Databases:
PubMed, Cochrane Library; Journals: Transgender Health, Journal of Sexual Medicine, JAMA Surgery, The
Lancet Psychiatry, International Journal of Transgender Health; Official resources: WPATH; LGBTQ+
surveys: NCTE, GLAAD. These sources provide a scientific foundation for clinical recommendations in
transgender health. Feminizing or masculinizing surgeries are effective in 85–94% of cases, significantly
reducing discrepancies in secondary sexual characteristics. Hormone therapy provides psychological
improvement in 70–80% of individuals, helping reduce symptoms of depression and anxiety. Specialized
psychological support increases treatment effectiveness in 60–75% of cases by facilitating emotional and social
adaptation during transition. Social support has a positive impact in 70–80% of cases, offering stability and
validation. A combined approach reduces depression by 70–85% and suicidal thoughts by 50–60%, with an
overall satisfaction rate of up to 90%. Combined therapeutic methods yield optimal outcomes, achieving 90%
satisfaction rates. Single method approaches are insufficient: Isolated social support lacks long-term
satisfaction, Hormone therapy covers only partial needs, Surgery without psychological and hormonal support
fails.
