Abstract:
Background. Primary bone lymphoma (PBL) represents a malignant lymphoid cell
neoplasm presenting with one or more bone lesions without nodal or extranodal
involvement. It constitutes 7% of primary malignant bone tumors and is considered to have
the best prognosis of all primary malignant bone tumors.
Objective(s). To study the incidence of primary bone lymphoma, as well as the
epidemiological, etiological, clinical and diagnostic characteristics to detect patients in the
early stages.
Materials and methods. An analytical, qualitative study was realized. The article involved
both research of the specialized literature and processing of information within the research
group. Patients were selected according to the inclusion criteria in the study. Subsequently,
the obtained data were processed using electronic computerized evaluation techniques.
Results. In the research group, PBL constituted 7% of the aggressive extranodal nonHodgkin lymphomas. The average age of diagnosis was 55 years with a slight female
predominance. Hereditary exostoses- 5%, sarcoidosis-7%, AIDS-5%, trauma (35%) were
incriminated as triggers of PBL. The most common was diffuse large B-cell lymphoma - 70%,
followed by B-cell lymphoblastic - 20%. 80% of patients were diagnosed with primary stage
IV. The clinical features of PBL were generally nonspecific, with osalgia being present in
100% of cases. The diagnosis of the disease is confirmed by histopathological and
immunohistochemical examination.
Conclusion(s). Primary bone lymphoma affects the working-age population and can
develop in any part of the skeleton. In most cases, the etiology remains unclear. Most
patients are diagnosed in the final stage of the disease, because the clinic is nonspecific and
often creates confusion.
