Abstract:
Background. Gout, a chronic inflammatory disease caused by the deposition of urate,
involves not only the joints but also the renal structures, generating complications with
severe evolution. Renal damage associated with gout is an underdiagnosed clinical entity,
but it has an essential role in the progression of CKD.
Objective(s). This synthesis aims to perform a critical, systematic, rigorous and
comprehensive review of the specialized literature in PubMed, Scopus regarding renal
complications of gout.
Materials and methods. We conducted a narrative review of the literature published to
date, using databases such as PubMed and Scopus. The inclusion criteria were:
observational, clinical, and experimental studies addressing the pathophysiological
mechanisms, clinical manifestations, diagnostic methods, and therapeutic options for renal
involvement in gout.
Results. Pathophysiological mechanisms: deposition of urate crystals triggers interstitial
inflammation with IL-1β, TNF-α and macrophage recruitment, leading to tubular fibrosis.
Decreased uric acid excretion favors recurrent crystalluria. Manifestations: nephrolithiasis
(25–40%), acute papillary necrosis with renal failure and crystals in the sediment, chronic
interstitial nephropathy with decreased eGFR. Diagnosis: ultrasound, non-contrast CT, eGFR
CKD-EPI, proteinuria, microalbuminuria, hematuria, 24 h urinary pH, biopsy, but rarely
used. Management: hypouricemic agents (allopurinol, febuxostat US <6 mg/dl),
alkalinization, hydration and BP control.
Conclusion(s). Renal damage in gout is multifactorial, polyetiological and often
underdiagnosed. Periodic screening of renal function, urine sediment examination and 24 h
pH help in detection. Hypouricemic therapy, adjusted to eGFR, plus alkalinization and
regular hydration, slow down the progression of lesions.
