Abstract:
Background. Drug resistant tuberculosis (TB) in diabetic patients represents the challenger
for TB control. Impairment of glycolic metabolism reduced cellular immunity, resistance to
insulin
Results. in affection of anti-TB drugs pharmacokinetics. Such patients are need the intensive
and longer therapeutic regimens.
Objective(s). The
Objective(s). of the study was to evaluate the clinical, laboratory investigations
particularities, and treatment outcomes of drug-resistant tuberculosis in patients with
diabetes mellitus.
Materials and methods. The research included 45 patients diagnosed with TB and diabetes
mellitus and undergoing treatment at the Municipal Clinical Hospital of
Phthisiopneumology, Chisinau during period 2022-2024. The patient’s clinical and
laboratory data were extracted from the observation sheets and statistically analyzed using
the non-parametric Fisher exact test.
Results. Resistant TB was dominated in patients aged 31–40 y.o. - 23(53%) cases, with Type
2 of Diabetes Miletus (DM) 41(91%), unemployed - 25(56%) patients. Labor migrants were
13(29%) patients. Comorbid status had 22(49%) patients (at least one comorbidity). The
most of cases (41/91.1%) were identified by passive case-finding with positive
Results. s of sputum smear in 27 (60.0%) cases. Household TB contact was identified in
9(42.9%) cases. Bilateral process with destruction had 22(48.9%) patients. The most prevalent resistance pattern was HRES in 10(22%) cases. Treatment success achieved in
27(60%) patients, 5(11.1%) patients died.
Conclusion(s). Management of TB in the presence of coexisting diabetes mellitus is difficult.
Patients are more sensitive to TB infection and at high risk of developing TB, with more rapid
progression of disease, raised likelihood of drug resistance, poor treatment outcomes,
therapeutic failure and death.
