Abstract:
Background. Sudden cardiac death (SCD) is a major cause of mortality. In emergency
settings, rapid risk detection is vital. Traditional risk assessment methods are insufficient.
Artificial intelligence (AI) applied to standard electrocardiography represents a promising
approach for improving early risk stratification.
Objective(s). To evaluate the performance of an AI model applied to standard 12-lead ECG
for predicting the risk of sudden cardiac death and to explore its integration into emergency
care in Republic of Moldova.
Materials and methods. The study analyzed 2510 SCD cases and 1325 controls from two
international cohorts (SUDS and Ventura PRESTO). Electrocardiograms were processed
using a convolutional neural network, and model performance was statistically evaluated
through AUROC, sensitivity, and specificity. Analyses were conducted using Python and R.
Results. The AI model showed high accuracy, with AUROC (Area Under the Receiver
Operating Characteristic curve) of 0.889 and 0.820, excelling conventional ECG scores
(0.712 and 0.743). Sensitivity was 84.3% and specificity 81.8%, showing the model correctly
identified most patients who had the risk and correctly excluded those who did not.
Combining the AI score with clinical data in logistic regression improved prediction,
increasing AUROC from 0.780 to 0.919 and from 0.806 to 0.899. These findings highlight the
AI model’s potential in early SCD risk detection and support its integration into clinical
decision-making processes.
Conclusion(s). Being non-invasive, cost-effective, and easy to implement, the AI-based ECG
model could become a valuable tool for SCD risk stratification in emergency departments in
the Republic of Moldova. It supports personalized, preventive care especially in time-critical
contexts.
