Abstract:
Background. Work-related low back pain is a common condition, associated with disability,
absenteeism and high socio-economic costs. Ozone therapy, through its anti-inflammatory,
analgesic and regenerative effects, represents an effective complementary method for the
treatment and rehabilitation of this pathology.
Objective(s). Analysis of the specialized literature on the effectiveness of ozone therapy in
the case of work-related low back pain, the mechanisms of action, methods of administration
and clinical benefits.
Materials and methods. For the study, relevant scientific articles were selected from
databases such as PubMed, Scopus, Google Academic and Web of Science. Clinical trials,
meta-analyses and synthesis papers published between 2005–2024, which evaluated and
argued the effectiveness of ozone therapy in occupational low back pain, were included.
Results. The literature review revealed that ozone therapy is effective in relieving pain and
improving lumbar function in patients with occupational low back pain. The included studies
reported significant reductions in pain (up to 60–70%) and disability, especially in cases
resistant to conventional treatments. The efficacy was similar or superior compared to
corticosteroids, physiotherapy and some minimally invasive procedures. Administration as
local injections have been shown to be safe, with a low adverse reaction profile. Evidence
also suggests an adjunctive role in preventing recurrences and accelerating professional
reintegration.
Conclusion(s). Ozone therapy, due to its anti-inflammatory and regenerative effects,
reduces pain and disability in occupational low back pain, offering a minimally invasive
alternative with a favorable safety profile. Although further studies are needed, it can be
recommended as a complementary option.
