Abstract:
Background. Senescence is an inevitable and irreversible process that induces changes in
all body systems as a
Results. of progressive structural and functional degeneration. Changes in the cardiovascular system mask the classic symptoms of angina pectoris, making it difficult to
establish a diagnosis in the early stages.
Objective(s). Analysis of scientific data on the impact of cardiovascular senescence on the
clinical picture of angina pectoris, aimed at establishing an early diagnosis and reducing
complications.
Materials and methods. Articles and medical publications published between 2015 and
2025, containing data on the impact of cardiovascular senescence on the clinical picture of
angina pectoris, were analyzed using sources such as Scopus, PubMed, Google Scholar, and
the Medical Scientific Library of the "Nicolae Testemițanu" University of Medicine and
Pharmacy.
Results. Degenerative cardiovascular processes such as vascular stiffness, reduced arterial
compliance, decreased coronary perfusion, diastolic and systolic dysfunction, myocardial
thickening and fibrosis, increase the risk of ischemia and atherosclerosis. Additionally,
reduced sensitivity of α-adrenergic and muscarinic receptors leads to a diminished
autonomic response. As a result, atypical symptoms may occur, such as diffuse chest or
epigastric discomfort without retrosternal pain or typical anginal radiation, exertional
dyspnea, marked fatigue, nausea, dizziness or syncope, often mistaken for other chronic
conditions in the elderly.
Conclusion(s). The analysis conducted confirms the major impact of senescence on the
classic clinical picture of angina pectoris, with the emergence of atypical forms that require
differential diagnosis to establish a timely diagnosis and reduce the risk of severe
complications in the elderly.
