Polimorfismul genei sintetazei endoteliale de oxid nitric la pacienţii cu sindrom coronarian acut

Abstract

The aim was to examine the effect of polymorphism of the endothelial nitric oxide synthase (eNOS) gene, located in the 4a/4b VNTR (variable number of tandem repeats) minisatelit marker of eNOS in patients with acute coronary syndrome. The career of the intron- 4a/4b and 4b/4b polymorphism of the eNOS gene was associated with atherosclerotic coronary lesion and increased risk of myocardial infarction. Larger studies are needed to understand the importance of eNOS gen in the coronary heart disease.

Scopul studiului a fost examinarea rolului polimorfismului genei sintetazei endoteliale de oxid nitric (eNOS), localizate pe markerul polimorf minisatelit eNOS-4a/4b VNTR (variable number of tandem repeats) la pacienţii cu sindrom coronarian acut (SCA). Portajul de alelele intron-4a/4b şi 4b/4b VNTR ale eNOS s-a asociat cu lezare aterosclerotică coronariană şi risc crescut de infarct miocardic. Sunt necesare studii largi pentru a înţelege importanţa polimorfismului genei eNOS în boala coronariană.