Sistemul glutationului în gliome

Abstract

Glutathione is an abundant natural tripeptide found within almost all cells. It instills several vital roles within a cell including antioxidation, maintenance of the redox state, modulation of the immune response and detoxification of xenobiotics. With respect to cancer, glutathione metabolism is able to play both protective and pathogenic roles. By conferring resistance to a number of chemotherapeutic drugs, elevated levels of glutathione in tumour cells are able to protect such cells in different type of cancers. This article presents a number of studies investigating the role of glutathione in promoting cancer, impeding chemotherapy, and the use of glutathione modulation to enhance antineoplastic therapy.

Articolul dat reprezintă un studiu integrativ cu privire la unul dintre cei mai puternici si importanţi antioxidanţi ai organismului, numit şi “antioxidantul miraculos” - glutationul. Sunt descrise rolurile sale patogenetice şi utilitatea lui în tratamentul maladiilor oncologice.