More trigger factors are known till this moment: the genetic factor (HLA B27, as well as there were proved the innate deficiencies of TLR 4 and NOD 2 as active actors in the host susceptibility to the infectious factors) ...

New information about pathogenesis, clinical manifestations and epidemiology of gout underline the necessity of profound studies of particularities of evolution of the disease in order to improve diagnostics and adequate ...

Frailty is a term widely used to denote a multidimensional syndrome of loss of reserves (energy, physical ability, cognition, health) that gives rise to vulnerability. It appears to be a valid construct, but how exactly ...

Right-sided infective endocarditis (RS IE) is considered to be the isolated lesion of the tricuspid valve and/or the pulmonary valve. RS IE develops only in 5 - 10% cases, affecting most frequently the young men. Although ...

Osteoporosis is a disorder dangerous by the lack of symptoms and severe complications such as fractures. FRAX tool is a universal instrument that has been recently elaborated and approved by International Osteoporosis ...

Alcohol consumption is wide spread all over the world. Although alcohol causes severe medical and socio-economical problems, in low doses it may prevent or regress the evolution of many diseases and increase life expectation. ...

The antiphospholipid syndrome (APS) is characterized by recurrent arterial and/or venous thrombosis and pregnancy morbidity manifested by early or late losses. Laboratory diagnosis of APS relies on the demonstration of a ...

The mechanisms leading to altered renal blood flow and renal function in patients with liver cirrhosis are not entirely clear. Renal vasoconstriction is believed to be secondary to a reduction in effective arterial volume ...

The study of the joint pathology have not only a special interest for the rheumatologists, traumatologists, radiologists, neurologists, but for specialists of the physical culture, sport and recuperation. According to ...

Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown etiology involving the sacroiliac joints and the axial skeleton, frequently being associated with significant extraskeletal features. Ocular disease, ...