Inhibina B marker în răspunsul ovarian

Abstract

Inhibin B is a heterodimetric glycoprotein released by the granulosa cells of the follicle. The low concentration was predictive for a poor ovarian response and decreased the success 137 during IVF cycles. Inhibin B concentrations in follicular fluid increase during the menstrual cycle correlated to the ovarian follicle development, proceeding with a mean of 19.2ng/ml in 5mm follicles, 409ng/ml in 14mm follicles, but with decline in 18 mm follicles to 275ng/ml. Keyword inhibin B, infertility, ovarian reserve, IVF

Inhibinele sunt hormoni polipeptidici heterodimerici care suprima selectiv secretia hipofizara de hormon foliculo-stimulant (FSH) si exercita actiuni paracrine locale asupra gonadelor. Formele finale ale moleculelor de inhibine au o greutate moleculara de aproximativ 32-36 kD si sunt alcatuite din 2 lanturi distincte α si β unite prin punti disulfidice. Numeroase studii atestă utilitatea determinării de inhibina B ca marker endocrin pentru monitorizarea funcţiei gonadale la ambele sexe. Cuvinte chee: inhibina B , infertilitate, rezerva ovariana, FIV