Abstract:
Inhibin B is a heterodimetric glycoprotein released by the granulosa cells of the follicle.
The low concentration was predictive for a poor ovarian response and decreased the success
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during IVF cycles. Inhibin B concentrations in follicular fluid increase during the menstrual
cycle correlated to the ovarian follicle development, proceeding with a mean of 19.2ng/ml in
5mm follicles, 409ng/ml in 14mm follicles, but with decline in 18 mm follicles to 275ng/ml.
Keyword inhibin B, infertility, ovarian reserve, IVF
Inhibinele sunt hormoni polipeptidici heterodimerici care suprima selectiv secretia
hipofizara de hormon foliculo-stimulant (FSH) si exercita actiuni paracrine locale asupra
gonadelor. Formele finale ale moleculelor de inhibine au o greutate moleculara de aproximativ
32-36 kD si sunt alcatuite din 2 lanturi distincte α si β unite prin punti disulfidice. Numeroase
studii atestă utilitatea determinării de inhibina B ca marker endocrin pentru monitorizarea
funcţiei gonadale la ambele sexe.
Cuvinte chee: inhibina B , infertilitate, rezerva ovariana, FIV
