Abstract:
The purpose of the study was to assess the influence of
Thiamethoxam TG (technical grade) pesticide (insecticide-neonicotinoid) produced by three different manufactures (test
substances T1, T2 and T3 each of them contains 95.5%, 95.4%
and 97% of active ingredient respectively) on fertility parameters of Wistar Han male rats. The studies were performed
exposing 40 Wistar Han male rats for each test substance in
two different doses (low dose of 1.5 mg kg and high dose of
15 mg kg). The detection of functional state of the gonads and
evaluation of the reproductive ability for males were performed
in the end of exposure period. The reproductive parameters
for intact females mated with exposed males were assessed
on the 20th day of pregnancy. The test substances T1 and T3 in
the maximum dose of 15 mg kg reveal signs of reproductive
toxicity only for exposed males. The test substance T2 in the
maximum dose in its turn reveal signs of reproductive toxicity
for exposed males and intact females. Based on the results we
can conclude that obtained effects are dose-dependent and
no effect levels are the same for all test substances (1.5 mg kg).
The observed additional embryotoxic effect at the maximum
dose for the test substance T2 presumably is the result of the
origin of the test substance.
Description:
Laboratory of Experimental Toxicology and Mutagenesis,
L.I. Medved’s Research Center of Preventive Toxicology,
Food and Chemical Safety MH, Ukraine, Kiev, Prima Conferință științifico-practică națională cu participare internațională ”Siguranţa chimică și toxicologia la confluenţa dintre domenii” 24-25 noiembrie 2016 Chișinău, Republica Moldova
